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The focal plane in the retina of the hyperopic eye, L2, <F, so contrary to the observed direction of speckle movement and frosted glass movement, and with the greater degree of hyperopia, the greater the distance of the focal plane of the retina hyperopia, speckle translation velocity. Also wear a certain degree of convex lenses, the speckle pattern observed for stationary production state. With the development of science. The study found that can make use of laser speckle imaging to monitor photodynamic therapy of vascular injury. Photodynamic therapy (PDT) is the smallest injury early cancer treatment, is also a palliative treatment for advanced cancer. Photodynamic therapy to selectively destroy local superficial tumors without endangering the normal tissue, and can be synergistic with chemotherapy and radiotherapy. It is the enhancement of design of Laser Pen.
Currently, photodynamic therapy to eliminate the tumor, there are three mechanisms: direct elimination of tumor cells; destruction of tumor cells surrounding blood vessels; activation of the immune response to prevent tumor cell growth after treatment. Survival and growth of tumor cells rely mainly around the tumor blood vessels that provide rich nutrients. In the past 15 years, how the study of photodynamic therapy to destroy tumor peripheral vascular and inhibit angiogenesis, the mechanism of attention has been paid but did not completely grasp. Assessment of vascular injury is only the diameter of blood vessels and the degree of injury associated with them, did not consider the impact of blood flow or perfusion rate. Laser imaging technology to study the velocity distribution of blood perfusion rate, and hemodynamic changes. It is as well as the quality and performance of Zumba DVD.
This will understand the mechanism of photodynamic therapy and vascular provide new research methods. Using laser speckle contrast imaging (LSCI, are) technology, on the chorioallantoic membrane (CAM) on the vascular diameter and blood flow velocity in real-time monitoring, and to assess the effect of photodynamic therapy in tumor surrounding vascular injury. In the photodynamic therapy process, due to the photosensitization reaction can be caused by microvascular damage, the release of inflammatory factors cause vasoconstriction, retention blood cell agglutination, blood stagnation caused by tissue edema, ischemia, hypoxia, thereby killing tumor. The experimental results show that laser speckle imaging techniques in real-time monitoring of the process of photodynamic therapy of vascular structure, blood flow velocity and blood perfusion changes. It is the features and advantages of laser pointers.
Minimum sensitivity of the minimum source density measurement error, and improve the light intensity, particle diameter and minimum sensitivity of optical imaging can improve the measurement accuracy, system performance to be able to shoot a single particle scattering images, in order to measure the absolute number of concentration. Pollution dispersion experiment is difficult to ensure that pollution sources to produce a uniform scale of smoke particles, and the smoke particles is difficult to ensure that the same geometry. The measurement of the concentration field measure only the relative concentrations of, rather than measuring absolute concentration, is due to the measurement of the relative amount of measurement error caused by the intensity of the light source, optical system absorption, reflectivity measurements automatically offset. It is because of measurement is the relative concentration. It is after many years’ development and research of laser pointers.